Spermatogenesis and folliculogenesis involve cell–cell interactions and gene expression
orchestrated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). FSH …

Congenital cryptorchidism (undescended testis) is one of the most common congenital
urogenital malformations in boys. Prevalence of cryptorchidism at birth among boys born …

Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1%
of men, are currently limited by the incomplete understanding of NOA pathogenesis and …

Oxidative stress is a condition determined by an imbalance between antioxidant and
oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed …

Hypogonadism is an endocrine disorder characterized by inadequate serum testosterone
production by the Leydig cells of the testis. It is triggered by alterations in the hypothalamic …

The coiled-coil domain-containing (CCDC) proteins have been implicated in a variety of
physiological and pathological processes. Their functional roles vary from their interaction …

Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

Pro-spermatogonia (SG) serve as the gateway to spermatogenesis. Using single-cell RNA
sequencing (RNAseq), we studied the development of ProSG, their SG descendants and …

Non-obstructive azoospermia (NOA) is a serious cause of male infertility. The Sertoli cell
responds to androgens and takes on roles supporting spermatogenesis, which may cause …

Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated
hypothalamic–pituitary–gonadal (HPG) axis event, plays important roles in reproduction and …