Puberty is characterized by major changes in the anatomy and function of reproductive
organs. Androgen activity is low before puberty, but during pubertal development, the testes …

Follicle-stimulating hormone (FSH) supports spermatogenesis acting via its receptor
(FSHR), which activates trophic effects in gonadal Sertoli cells. These pathways are targeted …

Estrogen signaling plays important roles in testicular functions and tumorigenesis. Fifteen
years ago, it was discovered that a member of the G protein-coupled receptor family …

Clinical manifestations and the need for treatment varies according to age in males with
hypogonadism. Early foetal-onset hypogonadism results in disorders of sex development …

Androgens are key for pubertal development of the mammalian testis, a phenomenon that is
tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signaling …

Spermatogenesis is a complex process occurring in mammalian testes, and constant sperm
production depends on the exact regulation of the microenvironment in the testes. Many …

RNA N 6-methyladenosine (m6A) modification is one of the principal post-transcriptional
modifications and plays a dynamic role in testicular development and spermatogenesis …

Spinal muscular atrophy (SMA) is one of the major genetic disorders associated with infant
mortality. More than 90% of cases of SMA result from deletions of or mutations in the …

In brief Minipuberty is a transient activity period of the hypothalamic–pituitary–gonadal axis
in the postnatal and infant period including surging serum concentrations of reproductive …

Context Despite the new opportunities provided by assisted reproductive technology (ART),
male infertility treatment is far from being optimized. One possibility, based on …