Intracellular lifestyle of Chlamydia trachomatis and host–pathogen interactions

K Stelzner, N Vollmuth, T Rudel - Nature Reviews Microbiology, 2023 - nature.com
In recent years, substantial progress has been made in the understanding of the intracellular
lifestyle of Chlamydia trachomatis and how the bacteria establish themselves in the human …

[HTML][HTML] Plasmid-mediated virulence in Chlamydia

BJ Turman, T Darville, CM O'Connell - Frontiers in Cellular and …, 2023 - frontiersin.org
Chlamydia trachomatis infection of ocular conjunctiva can lead to blindness, while infection
of the female genital tract can lead to chronic pelvic pain, ectopic pregnancy, and/or …

[HTML][HTML] Multipurpose prevention technologies: opportunities and challenges to ensure advancement of the most promising MPTs

B Young Holt, JA Turpin, J Romano - Frontiers in Reproductive …, 2021 - frontiersin.org
The HIV/sexually transmitted infection (STI) syndemics and the unmet need for modern
contraceptive methods continue to pose significant health risks for women worldwide (1) …

[PDF][PDF] Host cell death during infection with Chlamydia: a double-edged sword

BS Sixt - FEMS Microbiology Reviews, 2021 - academic.oup.com
The phylum Chlamydiae constitutes a group of obligate intracellular bacteria that infect a
remarkably diverse range of host species. Some representatives are significant pathogens …

Keeping the host alive–lessons from obligate intracellular bacterial pathogens

RK Loterio, DS Zamboni, HJ Newton - Pathogens and Disease, 2021 - academic.oup.com
Mammals have evolved sophisticated host cell death signaling pathways as an important
immune mechanism to recognize and eliminate cell intruders before they establish their …

[HTML][HTML] Pgp3 protein of Chlamydia trachomatis inhibits apoptosis via HO-1 upregulation mediated by PI3K/Akt activation

M Shu, J Bu, W Lei, L Chen, Z Zhou, C Lu, C Chen… - Microbial …, 2023 - Elsevier
As an obligate intracellular pathogen, Chlamydia trachomatis assumes various strategies to
inhibit host cells apoptosis, thereby providing a suitable intracellular environment to ensure …

LncRNA ZEB1-AS1/miR-1224-5p / MAP4K4 axis regulates mitochondria-mediated HeLa cell apoptosis in persistent Chlamydia trachomatis infection

F Luo, Y Wen, L Zhao, S Su, W Lei, L Chen, C Chen… - Virulence, 2022 - Taylor & Francis
Persistent infection of Chlamydia trachomatis is thought to be responsible for the debilitating
sequelae of blinding trachoma and infertility. Inhibition of host cell apoptosis is a persistent …

Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway

M Shu, W Lei, S Su, Y Wen, F Luo, L Zhao, L Chen… - Life Sciences, 2021 - Elsevier
Aim Chlamydia trachomatis has evolved various strategies to alleviate oxidative stress of
host cells to maintain their intracellular survival. However, the exact mechanism of anti …

[HTML][HTML] Chlamydia trachomatis Plasmid Protein pORF5 Up-Regulates ZFAS1 to Promote Host Cell Survival via MAPK/p38 Pathway

Y Wen, H Chen, F Luo, L Zhao, M Shu, S Su… - Frontiers in …, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in many
diseases. However, few studies have shown that lncRNAs take part in the pathogenesis of …

Chlamydia trachomatis induces lncRNA MIAT upregulation to regulate mitochondria‐mediated host cell apoptosis and chlamydial development

F Luo, Y Wen, L Zhao, S Su, Y Zhao… - Journal of cellular and …, 2022 - Wiley Online Library
Chlamydia trachomatis persistent infection is the leading cause of male prostatitis and
female genital tract diseases. Inhibition of host cell apoptosis is the key to maintaining …