Linkers or spacers are short amino acid sequences created in nature to separate multiple
domains in a single protein. Most of them are rigid and function to prohibit unwanted …

Technologies based on surface plasmon resonance (SPR) have allowed rapid, label‐free
characterization of protein‐protein and protein‐small molecule interactions. SPR has …

Multimeric peptide/class II MHC staining reagents were synthesized and shown to bind with
appropriate specificity to T cell hybridomas. A small, expanded population of T cells detected …

We have determined the structures of IA d covalently linked to an ovalbumin peptide (OVA
323–339) and to an influenza virus hemagglutinin peptide (HA 126–138). The floor of the …

Susceptibility to insulin-dependent diabetes mellitus is linked to MHC class II genes. The
only MHC class II molecule expressed by nonobese diabetic (NOD) mice, IA g7, shares a …

The utilization of optical biosensors to study molecular interactions continues to expand. In
1998, 384 articles relating to the use of commercial biosensors were published in 130 …

Association between the class II major histocompatibility complex (MHC) and the class II
invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the …

CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector
subsets after infection remains poorly defined. We examined CD4 T cells specific for the …

Direct identification and isolation of Ag-specific T cells became possible with the
development of MHC tetramers, based on fluorescent avidins displaying biotinylated peptide …

Proteins of the class II major histocompatibility complex (MHC) bind antigenic peptides that
are subsequently presented to T cells. Previous studies have shown that most of the …