Sar1 is an important and unique GTPase that regulates vesicle budding from the ER
membrane. An effort to crystallize full-length hamster Sar1 was unsuccessful owing to the …

MHC tetramers are reagents used for direct ex vivo analysis of the frequency and
phenotypes of antigen-specific T cells by flow cytometry. The tetramer staining assay is …

Abstract Systemic Lupus Erythematosus (SLE) c is a chronic autoimmune disease of
unknown etiology, although a combination of environmental, genetic and hormonal factors …

There is accelerating use of protein engineering by protein crystallographers. Site-directed
mutations are being used for a variety of purposes, including solubilizing the protein …

Abstract (DE) Antigen-reaktive CD4+ T-Zellen spielen eine wichtige Rolle bei der
Entwicklung schützender Immunität. So sind Kenntnisse über die Bildung und Erhaltung …

Voltage gated sodium channels (VGSCs) play an important role in propagating action
potentials. Calmodulin (CaM) is known to modulate the inactivation kinetics of VGSCs by …

Les molécules classiques du CMH de classe II présentent des peptides antigéniques aux
lymphocytes T CD4+. Cette présentation est régulée par deux molécules non classiques …

Abstract The MHC Class II molecule binds peptide in a complex intracellular process for
presentation to T cells and subsequent initiation of a T-helper immune response. Described …

Another commonly encountered situation is that crystals can be obtained, but they diffract
poorly. There are many examples where investigators have applied protein engineering in …

The triggering of the immune response by antigenic presentation is essential when there is
invasion of pathogenic agents in the body. The antigen presenting celis (APC) internalize …