An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis
N Garg, TW Smith - Brain and behavior, 2015 - Wiley Online Library
Background Multiple sclerosis is an acquired demyelinating disease of the central nervous
system. It is the second most common cause of disability in adults in United States after head …
system. It is the second most common cause of disability in adults in United States after head …
Pathology of multiple sclerosis and related inflammatory demyelinating diseases
A Kutzelnigg, H Lassmann - Handbook of clinical neurology, 2014 - Elsevier
This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …
including recent insights into its molecular neuropathology and immunology. It shows that all …
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
V Viglietta, C Baecher-Allan, HL Weiner… - The Journal of …, 2004 - rupress.org
CD4+ CD25+ regulatory T cells contribute to the maintenance of peripheral tolerance by
active suppression because their deletion causes spontaneous autoimmune diseases in …
active suppression because their deletion causes spontaneous autoimmune diseases in …
New concepts in the immunopathogenesis of multiple sclerosis
B Hemmer, JJ Archelos, HP Hartung - Nature Reviews Neuroscience, 2002 - nature.com
Multiple sclerosis (MS) is a commonly occurring inflammatory and demyelinating
neurological disease. It has been considered to be an autoimmune disorder mediated by …
neurological disease. It has been considered to be an autoimmune disorder mediated by …
[HTML][HTML] The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS
H Wulff, PA Calabresi, R Allie, S Yun… - The Journal of …, 2003 - Am Soc Clin Investig
Through a combination of fluorescence microscopy and patch-clamp analysis we have
identified a striking alteration in K+ channel expression in terminally differentiated human …
identified a striking alteration in K+ channel expression in terminally differentiated human …
Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease
Objective Myelin oligodendrocyte glycoprotein (MOG) is a candidate target antigen in
demyelinating diseases of the central nervous system (CNS). Although MOG is …
demyelinating diseases of the central nervous system (CNS). Although MOG is …
Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis
A Bar‐Or, RK Nuttall, M Duddy, A Alter, HJ Kim… - Brain, 2003 - academic.oup.com
Matrix metalloproteinases (MMPs) are implicated in multiple sclerosis where one of their
roles may be to facilitate the transmigration of circulating leukocytes into the CNS. Studies …
roles may be to facilitate the transmigration of circulating leukocytes into the CNS. Studies …
Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes
C Natarajan, JJ Bright - The Journal of Immunology, 2002 - journals.aai.org
Experimental allergic encephalomyelitis (EAE) is a CD4+ Th1 cell-mediated inflammatory
demyelinating autoimmune disease of the CNS that serves as an animal model for multiple …
demyelinating autoimmune disease of the CNS that serves as an animal model for multiple …
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis
L Lovato, SN Willis, SJ Rodig, T Caron… - Brain, 2011 - academic.oup.com
In the central nervous system of patients with multiple sclerosis, B cell aggregates populate
the meninges, raising the central question as to whether these structures relate to the B cell …
the meninges, raising the central question as to whether these structures relate to the B cell …