Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenesis by …

A wide spectrum of clinical manifestations has become a hallmark of the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic, although the …

Down's syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth
impairments. Individuals with DS are also prone to severe infections and autoimmunity …

Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways
have been described in extraordinary molecular detail, mainly from studies of B cell …

The COVID pandemic has refreshed and expanded recognition of the vital role that
sustained antibody (Ab) secretion plays in our immune defenses against microbes and of …

Acute COVID-19, caused by SARS-CoV-2, is characterized by diverse clinical presentations,
ranging from asymptomatic infection to fatal respiratory failure, and often associated with …

Uveitis is a severe autoimmune disease, and a common cause of blindness; however, its
individual cellular dynamics and pathogenic mechanism remain poorly understood. Herein …

Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are both types
of lupus, yet the characteristics, and differences between them are not fully understood. Here …

Human B cells could be divided into four classical subsets based on CD27 and
immunoglobulin (Ig) D expression. Distinct from the other three well-studied subsets, CD27 …