[HTML][HTML] CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in …

L Gan, D Liu, J Liu, E Chen, C Chen, L Liu… - … and Targeted Therapy, 2021 - nature.com
CD38 is the main enzyme for nicotinamide adenine dinucleotide (NAD) degradation in
mammalian cells. Decreased NAD levels are closely related to metabolic syndromes and …

Sudan Black B, the specific histochemical stain for lipofuscin: a novel method to detect senescent cells

K Evangelou, VG Gorgoulis - Oncogene-induced senescence: Methods …, 2017 - Springer
Abstract The Sudan-Black-B (SBB) histochemical stain is well known to specifically react
against lipofuscin, an aggregate of oxidized proteins, lipids, and metals. Lipofuscin is related …

Ionizing radiation-induced cellular senescence promotes tissue fibrosis after radiotherapy. A review

HQ Nguyen, NH To, P Zadigue, S Kerbrat… - Critical reviews in …, 2018 - Elsevier
Ionizing radiation-exposure induces a variety of cellular reactions, such as senescence and
apoptosis. Senescence is a permanent arrest state of the cell division, which can be …

Aging diagnostic probe for research on aging and evaluation of anti-aging drug efficacy

Z Li, J Cheng, L Huang, W Li, Y Zhao… - Analytical Chemistry, 2021 - ACS Publications
Aging is a biological process, and its gradual degeneration of physiological functions leads
to an increase in morbidity and mortality. At present, more and more studies on aging and …

[HTML][HTML] ROS-induced activation of DNA damage responses drives senescence-like state in postmitotic cochlear cells: implication for hearing preservation

N Benkafadar, F François, C Affortit, F Casas… - Molecular …, 2019 - Springer
In our aging society, age-related hearing loss (ARHL) has become a major socioeconomic
issue. Reactive oxygen species (ROS) may be one of the main causal factors of age-related …

[HTML][HTML] Involvement of oxidative stress in placental dysfunction, the pathophysiology of fetal death and pregnancy disorders

Z Sultana, Y Qiao, K Maiti, R Smith - Reproduction, 2023 - rep.bioscientifica.com
In brief Placental oxidative stress contributes to both normal and abnormal placentation
during pregnancy. This review discusses the potential consequence of oxidative stress …

Chemical Strategies for the Detection and Elimination of Senescent Cells

J García-Fleitas, A García-Fernández… - Accounts of Chemical …, 2024 - ACS Publications
Conspectus Cellular senescence can be defined as an irreversible stopping of cell
proliferation that arises in response to various stress signals. Cellular senescence is …

[HTML][HTML] Integrating environment and aging research: opportunities for synergy and acceleration

KMC Malecki, JK Andersen, AM Geller… - Frontiers in aging …, 2022 - frontiersin.org
Despite significant overlaps in mission, the fields of environmental health sciences and
aging biology are just beginning to intersect. It is increasingly clear that genetics alone does …

Ageing, cellular senescence and chronic kidney disease: experimental evidence

H Tan, J Xu, Y Liu - Current opinion in nephrology and …, 2022 - journals.lww.com
Ageing, cellular senescence and chronic kidney disease: expe... : Current Opinion in Nephrology
and Hypertension Ageing, cellular senescence and chronic kidney disease: experimental …

Inducers of senescence, toxic compounds, and senolytics: The multiple faces of Nrf2‐activating phytochemicals in cancer adjuvant therapy

M Malavolta, M Bracci, L Santarelli… - Mediators of …, 2018 - Wiley Online Library
The reactivation of senescence in cancer and the subsequent clearance of senescent cells
are suggested as therapeutic intervention in the eradication of cancer. Several natural …