Abstract IGF-1 receptor (IGF-1R) signaling is implicated in cardiac hypertrophy and
longevity. However, the role of IGF-1R in age-related cardiac remodeling is only partially …

In recent years, the health‐promoting effects of the citrus flavanone naringenin have been
examined. The results have provided evidence for the modulation of some key mechanisms …

Background Chronic cardiotoxicity is less common in male than in female patients receiving
doxorubicin and other anthracyclines at puberty and adolescence. We hypothesized that this …

Cellular senescence represents the state of irreversible cell cycle arrest during cell division.
Cellular senescence not only plays a role in diverse biological events such as …

The subject of the work concerns the dermatological management of patients mainly with
aged skin. The purpose of the work was to present the basic techniques and preparations …

The possibility to target cellular senescence with natural bioactive substances open
interesting therapeutic perspective in cancer and aging. Engaging senescence response is …

Epithelial–mesenchymal transition (EMT) is a cellular process by which differentiated
epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has …

Brain organoids are valuable research models for human development and disease since
they mimic the various cell compositions and structures of the human brain; however, they …

Telomere shortening is the main molecular mechanism of aging, but not the only one. The
adaptive immune system also ages, and older organisms tend to develop a chronic pro …

Background Aging involves multiple biologically complex processes characterized by a
decline in cellular homeostasis over time leading to a loss and impairment of physiological …