The possibility to target cellular senescence with natural bioactive substances open
interesting therapeutic perspective in cancer and aging. Engaging senescence response is …

Epithelial–mesenchymal transition (EMT) is a cellular process by which differentiated
epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has …

Peritubular capillary (PTC) rarefaction along with tissue fibrosis is a hallmark of chronic
kidney disease (CKD). However, molecular mechanisms of PTC loss have been poorly …

Objective—α7 nicotinic acetylcholine receptor (α7nAChR) is a subtype of nAChR and has
been reported to be involved in hypertension end-organ damage. In this study, we tested the …

Regulated in development and DNA damage response-1 (Redd1) is a stress-response
gene that is transcriptionally induced by diverse stressful stimuli to influence cellular growth …

Clinical translation of nanotechnologies has limited success, at least in part, due to the
existence of several overlooked factors on the nature of the nanosystem (eg …

Brain organoids are valuable research models for human development and disease since
they mimic the various cell compositions and structures of the human brain; however, they …

Background and Purpose: Incidence of cardiovascular disorders increases with age,
because of a dramatic fall of endogenous self-defense mechanisms and increased …

Cellular senescence is a state of durable cell cycle arrest with metabolic activities distinct
from those of the proliferative state. Since senescence was originally reported to be induced …

Dysfunction of the human trabecular meshwork (HTM) plays a central role in the age-
associated disease glaucoma, a leading cause of irreversible blindness. The etiology …