Sox4 expression is restricted in mammals to embryonic structures and some adult tissues,
such as lymphoid organs, pancreas, intestine, and skin. During embryogenesis, Sox4 …

Background Over the life course, African American (AA) women have faster telomere
attrition, a biological indicator of accelerated aging, than White women. Race, sex, age, and …

Cryptosporidium, a ubiquitous coccidian protozoan parasite that infects the gastrointestinal
epithelium and other mucosal surfaces, is an important opportunistic pathogen for …

A new senescence-responsive fluorescent probe (SRP) was developed for the detection of β-
galactosidase activity in senescent cells. UV-absorption of t probe SRP at 495 nm was …

Background Ultraviolet light exposure generates, in human tissues, radical species, which
represent the main cause of photo-aging, DNA damage and skin cancer onset. On the other …

Detection of senescence-associated β-galactosidase (SA-β-gal) activity at an increased
lysosomal pH is one of the most reliable approaches for probing senescent cells. Herein, we …

Polyunsaturated fatty acids (PUFA), a group of nourishing and health-promoting nutrients,
ameliorate age-related chronic diseases. However, how PUFA especially n-3 PUFA exert …

Angiotensin II can cause oxidative stress and increased blood pressure that result in long
term cardiovascular pathologies. Here we evaluated the contribution of cellular senescence …

Heart failure is a typical age-associated disease. However, the mechanism by which heart
function declines and heart failure increases in association with age is not clear. Recent …

Conspectus Cellular senescence can be defined as an irreversible stopping of cell
proliferation that arises in response to various stress signals. Cellular senescence is …