Cellular senescence refers to a state of irreversible arrest of cell proliferation in response to
various forms of cellular stress. It is known that the accumulation of senescent cells is a …

Objective Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress
response of DNA damage, which is involved in DNA damage repair and cellular …

Aging is associated with a decline in cardiac function due to a decreased myocardial
reserve. This adverse cardiac remodeling comprises of a variety of changes, including a …

Multicellular spheroids have proven suitable as three-dimensional in vivo-like models of non-
vascularized micrometastases. Unlike monolayer‑based models, spheroids mirror the …

Objective—Smooth muscle (SM) 22α, an actin-binding protein, displays an upregulated
expression as a marker during cellular senescence. However, the causal relationship …

Background: Peritoneal carcinomatosis (PC) is a terminal evolution from primary colorectal
cancer (pCRC) associated with poor patient survival. Impact of the immune cell infiltrate on …

Background Liver is the crucial organ as a hub for metabolic reactions. p16 (INK4a) is a well-
established cyclin-dependent kinase (CDK) inhibitor that plays important role in the …

Background Cellular senescence is induced either internally, for example by replication
exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular …

The aging heart is characterized by a number of structural changes leading to ventricular
stiffness, impaired resistance to stress and increased risk of developing heart failure (HF) …

Objective To evaluate the consequences of plasma from individuals with obesity on
parameters associated with immunosenescence in unrelated healthy peripheral blood …