The actin-based foot processes of kidney podocytes and the interposed slit diaphragm form
the final barrier to proteinuria. Mutations affecting several podocyte proteins cause …

Kidney podocytes are highly differentiated epithelial cells that form interdigitating foot
processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte …

Classically, infants with mutations in NPHS1, which encodes nephrin, present with nephrotic
syndrome within the first 3 mo of life (congenital nephrotic syndrome of the Finnish-type) …

Rho family GTPases are molecular switches best known for their pivotal role in dynamic
regulation of the actin cytoskeleton. The prototypic members of this family are Cdc42, Rac1 …

Mutations in the NPHS1 gene cause congenital nephrotic syndrome of the Finnish type
presenting before the first 3 months of life. Recently, NPHS1 mutations have also been …

Background. Cellular insulin resistance is the hallmark of type 2 diabetes and predominantly
affects adipose and muscle cells. The saturated free fatty acid palmitate is elevated in insulin …

Hemopexin is an abundant plasma protein that effectively scavenges heme. When infused
into rats, hemopexin induces reversible proteinuria, and activated hemopexin is increased in …

Podocytes are significant in establishing the glomerular filtration barrier. Sustained rennin–
angiotensin system (RAS) activation is crucial in the pathogenesis of podocyte injury and …

Invadopodia are actin-based projections enriched with proteases, which invasive cancer
cells use to degrade the extracellular matrix (ECM). The Phox homology (PX)-Src homology …

Possible roles of anti-nephrin antibodies in post-transplant recurrent focal segmental
glomerulosclerosis (FSGS) have been reported recently. To confirm these preliminary …