Periodontitis exacerbates and promotes the progression of chronic kidney disease through oral flora, cytokines, and oxidative stress

L Li, YL Zhang, XY Liu, X Meng, RQ Zhao… - Frontiers in …, 2021 - frontiersin.org
Periodontitis is a type of systemic immune inflammation that is caused by the complex
infection of a variety of microorganisms in the subgingival plaque and the imbalance of the …

[HTML][HTML] Oral and gut microbial dysbiosis and non-alcoholic fatty liver disease: the central role of Porphyromonas gingivalis

T Wang, T Ishikawa, M Sasaki, T Chiba - Frontiers in medicine, 2022 - frontiersin.org
Gut microbiota play many important roles, such as the regulation of immunity and barrier
function in the intestine, and are crucial for maintaining homeostasis in living organisms. The …

[HTML][HTML] TLR2 activation by porphyromonas gingivalis requires both PPAD activity and fimbriae

A Wielento, GP Bereta, KB Łagosz-Ćwik… - Frontiers in …, 2022 - frontiersin.org
Porphyromonas gingivalis, a keystone oral pathogen implicated in development and
progression of periodontitis, may also contribute to the pathogenicity of diseases such as …

Phylogenomic analysis of the Porphyromonas gingivalis - Porphyromonas gulae duo: approaches to the origin of periodontitis

M Morales-Olavarría, J Nuñez-Belmar… - Frontiers in …, 2023 - frontiersin.org
Porphyromonas gingivalis is an oral human pathogen associated with the onset and
progression of periodontitis, a chronic immune-inflammatory disease characterized by the …

Streptococcus gordonii programs epithelial cells to resist ZEB2 induction by Porphyromonas gingivalis

J Ohshima, Q Wang, ZR Fitzsimonds… - Proceedings of the …, 2019 - National Acad Sciences
The polymicrobial microbiome of the oral cavity is a direct precursor of periodontal diseases,
and changes in microhabitat or shifts in microbial composition may also be linked to oral …

The complement system as a key modulator of the oral microbiome in health and disease

RO Mattos-Graner, MI Klein… - Critical Reviews in …, 2024 - Taylor & Francis
In this review, we address the interplay between the complement system and host
microbiomes in health and disease, focussing on oral bacteria known to contribute to …

Production and properties of adhesin-free gingipain proteinase RgpA

ASM Mahmud, CA Seers, NL Huq, L Zhang… - Scientific Reports, 2023 - nature.com
The Arg-specific gingipains of Porphyromonas gingivalis RgpA and RgpB have 97%
identical sequences in their catalytic domains yet their propeptides are only 76% identical …

Accessory fimbrial subunits and PPAD are necessary for TLR2 activation by Porphyromonas gingivalis

A Wielento, GP Bereta, K Szczęśniak… - Molecular Oral …, 2023 - Wiley Online Library
Porphyromonas gingivalis is an oral pathogen that promotes dysbiosis by quenching the
bactericidal activity of the host immune system while maintaining chronic inflammation …

Humanized mouse models for the study of periodontitis: an opportunity to elucidate unresolved aspects of its immunopathogenesis and analyze new …

C Rojas, MP García, AF Polanco… - Frontiers in …, 2021 - frontiersin.org
Periodontitis is an oral inflammatory disease in which the polymicrobial synergy and
dysbiosis of the subgingival microbiota trigger a deregulated host immune response, that …

Outer Membrane Vesicle Proteome of Porphyromonas gingivalis Is Differentially Modulated Relative to the Outer Membrane in Response to Heme Availability

PD Veith, C Luong, KH Tan, SG Dashper… - Journal of proteome …, 2018 - ACS Publications
Porphyromonas gingivalis is an anaerobic, Gram-negative oral pathogen associated with
chronic periodontitis. P. gingivalis has an obligate requirement for heme, which it obtains …