Numerous regulatory peptides play a critical role in the pathogenesis of airway
inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma …

Regulatory neuropeptides control and regulate breathing in physiological and
pathophysiological conditions. While they have been identified in the neurons of major …

Unpleasant sensory and emotional experiences originating from the respiratory system,
such as dyspnea, breathlessness, unsatisfied inspiration or air hunger are not immediately …

Tachykinins are important in the development of pulmonary inflammation in mice but the
tachykinin receptor subtype mediating this response has not been defined. To elucidate the …

Publisher Summary This chapter focuses on the progress in the development of neurokinin
(NK) antagonists. The neurokinins substance P (SP), neurokinin A (NKA), and neurokinin B …

Neurokinin A (NKA) causes bronchoconstriction in asthmatic patients. In vitro both NK1 and
NK2 receptors can mediate airway contraction. Moreover in guinea pigs, NK3 receptors …

Experiments were performed to characterize the pharmacology of SCH 206272 [(R, R)-1′[5-
[(3, 5-dichlorobenzoyl) methylamino]-3-(3, 4-dichlorophenyl)-4 (Z)-(methoxyimino) pentyl]-N …

Mechanism mediating the testicular toxicity induced by CS-003, a triple neurokinin receptor
antagonist, was investigated in male dogs. Daily CS-003 administrations showed testicular …

Neurokinins are known to induce neurogenic inflammation related to respiratory diseases.
The effects of CS-003 ([1-{2-[(2R)-(3, 4-dichlorophenyl)-4-(3, 4, 5-trimethoxybenzoyl) …

Airway hyperresponsiveness is a cardinal feature of asthma. Lung C-fiber activation induces
central and local defense reflexes that may contribute to airway hyperresponsiveness. Initial …