In this study, we investigated the involvement of neurokinin NK3 receptors in a severe
asthma model prepared by administering ovalbumin via inhalation three times to …

Objective and design To determine whether RBL-2H3 cells have endogenous substance P
(SP) expression under immunoglobulin E (IgE)-activated and inactivated conditions, and to …

The synthesis and binding affinity for hNK1 and hNK2 receptors of a series of diacyl
substituted 2-aryl piperazines are described. SAR evaluation led to the racemic derivative …

Based on the structure of N-[(R, R)-(E)-1-(4-chlorobenzyl)-3-(2-oxoazepan-3-yl) carbamoyl]
allyl-N-methyl-3, 5-bis (trifluoromethyl) benzamide (1), attempts to improve the NK2 affinity …

Neurokinins (NKs), also known as tachykinins (TKs), are members of a family of small
peptides sharing the common C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH2 (1 …

Background: Involvement of neurokinins in asthma has been previously pointed out by
several reports. However, the relationship between neurokinins and the severity of asthma …

The stereoselective synthesis of N-[(R, R)-(E)-1-(4-chloro-benzyl)-3-(2-oxo-azepan-3-
ylcarbamoyl)-allyl]-N-methyl-3, 5-bis-trifluoromethyl-benzamide (4) and its NK1 and NK2 …

The equivocal experimental and epidemiological evidence of bitumen fumes and the
possible mechanisms of toxicity remain uncertain. This study therefore aimed at …

Cough is frequently associated with a wide array of respiratory infections, ailments and
disorders. Consequently, cough is the number one symptomatic reason why people visit …

In a continuation of our efforts to simplifly the structure of our neurokinin antagonists, a series
of substituted biphenyl derivatives has been prepared. Several compounds exhibit potent …