The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

There is much cellular heterogeneity in the tumor microenvironment. The tumor epithelia
and stromal cells co-evolve, and this reciprocal relationship dictates almost every step of …

Cancer microenvironment is created not only by malignant epithelial cells, but also by
several kinds of stromal cells. Since Paget proposed the “seed and soil” hypothesis, the …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor
development and normal development of the lung, kidney, and lymphatic vascular systems …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …

Compelling evidence show that reactive oxygen species (ROS) levels are finely regulated in
the cell and can act as “second messengers” in response to diverse stimuli. In tumor …

Prognostication is an integral part of cancer diagnostic and helps oncologists to guide
treatment decisions and therapy intensity. Accumulating evidence suggest that the stroma …

Cells respond to both chemical and mechanical cues present within their microenvironment.
Various mechanical signals are detected by and transmitted to the cells through …

Cancerous tissue is a complex mix of tumor cells, stromal cells and extracellular matrix
(ECM), all of which make up a disordered and aggressive niche in comparison with …