Hypervalent aryliodoumiums are intensively investigated as arylating agents. They are
excellent surrogates to aryl halides, and moreover they exhibit better reactivity, which allows …

Introduction Sulfur-containing functional groups are privileged motifs that occur in various
pharmacologically effective substances and several natural products. Various functionalities …

A novel class of photoswitches based on a phenylazothiazole scaffold that undergoes
reversible isomerization under visible-light irradiation is reported. The photoswitch, which …

Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of
synthetic compounds. Its diverse pharmacological activity is reflected in many clinically …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Introduction Hybrid drug design has developed as a prime method for the development of
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …

Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …

Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …

Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …

It is a major concern to treat cancer successfully, due to the distinctive pathophysiology of
cancer cells and the gradual manifestation of resistance. Specific action, adverse effects and …