The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
Dopamine and addiction: what have we learned from 40 years of research
Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known.
The critical role of DA in addiction is supported by converging evidence that has been …
The critical role of DA in addiction is supported by converging evidence that has been …
Structural and functional plasticity of dendritic spines–root or result of behavior?
CD Gipson, MF Olive - Genes, Brain and Behavior, 2017 - Wiley Online Library
Dendritic spines are multifunctional integrative units of the nervous system and are highly
diverse and dynamic in nature. Both internal and external stimuli influence dendritic spine …
diverse and dynamic in nature. Both internal and external stimuli influence dendritic spine …
Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
The nucleus accumbens (NAc) is considered a hub of reward processing and a growing
body of evidence has suggested its crucial role in the pathophysiology of major depressive …
body of evidence has suggested its crucial role in the pathophysiology of major depressive …
Therapeutic potentials of ketamine and esketamine in obsessive–compulsive disorder (OCD), substance use disorders (SUD) and eating disorders (ED): a review of …
G Martinotti, S Chiappini, M Pettorruso, A Mosca… - Brain Sciences, 2021 - mdpi.com
The obsessive–compulsive spectrum refers to disorders drawn from several diagnostic
categories that share core features related to obsessive–compulsive disorder (OCD), such …
categories that share core features related to obsessive–compulsive disorder (OCD), such …
Astrocyte regulation of synaptic signaling in psychiatric disorders
Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …
Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis
MD Scofield, PW Kalivas - The Neuroscientist, 2014 - journals.sagepub.com
Addiction is characterized as a chronic relapsing disorder whereby addicted individuals
persistently engage in drug seeking and use despite profound negative consequences. The …
persistently engage in drug seeking and use despite profound negative consequences. The …
Gray and white matter morphology in substance use disorders: a neuroimaging systematic review and meta-analysis
V Pando-Naude, S Toxto, S Fernandez-Lozano… - Translational …, 2021 - nature.com
Substance use disorders (SUDs) are characterized by a compulsion to seek and consume
one or more substances of abuse, with a perceived loss of control and a negative emotional …
one or more substances of abuse, with a perceived loss of control and a negative emotional …
Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens
CD Teague, EJ Nestler - Molecular psychiatry, 2022 - nature.com
Repeated cocaine use induces coordinated changes in gene expression that drive plasticity
in the nucleus accumbens (NAc), an important component of the brain's reward circuitry, and …
in the nucleus accumbens (NAc), an important component of the brain's reward circuitry, and …
Architectural representation of valence in the limbic system
In order to thrive, animals must be able to recognize aversive and appetitive stimuli within
the environment and subsequently initiate appropriate behavioral responses. This …
the environment and subsequently initiate appropriate behavioral responses. This …