Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …
Transport selectivity of nuclear pores, phase separation, and membraneless organelles
HB Schmidt, D Görlich - Trends in biochemical sciences, 2016 - cell.com
Nuclear pore complexes (NPCs) provide a selective passageway for receptor-mediated
active transport between nucleus and cytoplasm, while maintaining the distinct molecular …
active transport between nucleus and cytoplasm, while maintaining the distinct molecular …
Transport between the cell nucleus and the cytoplasm
▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …
The yeast nuclear pore complex: composition, architecture, and transport mechanism
MP Rout, JD Aitchison, A Suprapto, K Hjertaas… - The Journal of cell …, 2000 - rupress.org
An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic
exchange requires a comprehensive inventory of the molecular components of the NPC and …
exchange requires a comprehensive inventory of the molecular components of the NPC and …
Transport into and out of the nucleus
IG Macara - Microbiology and molecular biology reviews, 2001 - Am Soc Microbiol
SUMMARY A defining characteristic of eukaryotic cells is the possession of a nuclear
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …
[HTML][HTML] Kinetic analysis of translocation through nuclear pore complexes
The mechanism of facilitated translocation through nuclear pore complexes (NPCs) is only
poorly understood. Here, we present a kinetic analysis of the process using various model …
poorly understood. Here, we present a kinetic analysis of the process using various model …
Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity
HB Schmidt, D Görlich - Elife, 2015 - elifesciences.org
Nuclear pore complexes (NPCs) conduct massive transport mediated by shuttling nuclear
transport receptors (NTRs), while keeping nuclear and cytoplasmic contents separated. The …
transport receptors (NTRs), while keeping nuclear and cytoplasmic contents separated. The …
[HTML][HTML] The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion
Nuclear pore complexes (NPCs) restrict the nucleocytoplasmic flux of most macromolecules,
but permit facilitated passage of nuclear transport receptors and their cargo complexes. We …
but permit facilitated passage of nuclear transport receptors and their cargo complexes. We …
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle
K Weis - Cell, 2003 - cell.com
Macromolecular transport between the cytoplasm and the nucleus occurs through the
nuclear pore complex (NPC) and is mediated by multiple families of soluble transport …
nuclear pore complex (NPC) and is mediated by multiple families of soluble transport …
Nucleocytoplasmic transport
D Görlich, S Jäkel - Protein Targeting, Transport, and Translocation, 2002 - Elsevier
Publisher Summary This chapter outlines the nucleocytoplasmic transport. The cell nucleus
is the most prominent cellular organelle and the defining feature of the eukaryotic branch of …
is the most prominent cellular organelle and the defining feature of the eukaryotic branch of …