Reactive oxygen species regulate T cell immune response in the tumor microenvironment

X Chen, M Song, B Zhang… - Oxidative Medicine and …, 2016 - Wiley Online Library
Reactive oxygen species (ROS) produced by cellular metabolism play an important role as
signaling messengers in immune system. ROS elevated in the tumor microenvironment are …

Anticancer potential of resveratrol, β-lapachone and their analogues

DC Ferraz da Costa, L Pereira Rangel… - Molecules, 2020 - mdpi.com
This review aims to explore the potential of resveratrol, a polyphenol stilbene, and beta-
lapachone, a naphthoquinone, as well as their derivatives, in the development of new drug …

Oxidative stress produced by hyperthyroidism status induces the antioxidant enzyme transcription through the activation of the Nrf‐2 factor in lymphoid tissues of Balb …

M Costilla, R Macri Delbono, A Klecha… - Oxidative medicine …, 2019 - Wiley Online Library
Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid
hormones T3 and T4. Thyroid hormones exert pleiotropic actions on numerous tissues and …

Natural naphthoquinones with great importance in medicinal chemistry

F de Carvalho da Silva… - Current Organic …, 2016 - ingentaconnect.com
This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone,
examples of bioactive natural products that still being under biological evaluation and …

[HTML][HTML] Effects of a novel β–lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis

DO Dos Anjos, ESS Alves, VT Gonçalves… - International Journal for …, 2016 - Elsevier
Natural products comprise valuable sources for new antiparasitic drugs. Here we tested the
effects of a novel β–lapachone derivative on Trypanosoma cruzi parasite survival and …

Cold plasma treatment of patient‐derived chronic lymphocytic B‐cell leukemia enhances cytotoxic T‐cell proliferation

M Golpour, H Asgarian‐Omran… - Plasma Processes …, 2024 - Wiley Online Library
Cold physical plasma, a partially ionized gas, has been shown to be effective in treating
chronic wounds and cancer. However, there is limited research on plasma exposure of …

Potential of 2-Hydroxy-3-Phenylsulfanylmethyl-[1,4]-Naphthoquinones against Leishmania (L.) infantum: Biological Activity and Structure-Activity Relationships

EG Pinto, IO Santos, TJ Schmidt, SET Borborema… - PLoS …, 2014 - journals.plos.org
Naphtoquinones have been used as promising scaffolds for drug design studies against
protozoan parasites. Considering the highly toxic and limited therapeutic arsenal, the global …

Polychlorinated biphenyl quinone metabolite promotes p53-dependent DNA damage checkpoint activation, S-phase cycle arrest and extrinsic apoptosis in human …

X Song, L Li, Q Shi, HJ Lehmler, J Fu… - Chemical research in …, 2015 - ACS Publications
Polychlorinated biphenyls (PCBs) are a group of persistent organic pollutants. The toxic
behavior and mechanism of PCBs individuals and congeners have been extensively …

Polyphenol‐Rich Fraction from Larrea divaricata and its Main Flavonoid Quercetin‐3‐Methyl Ether Induce Apoptosis in Lymphoma Cells Through Nitrosative Stress

R Martino, MLB Arcos, R Alonso, V Sülsen… - Phytotherapy …, 2016 - Wiley Online Library
Larrea divaricata is a plant with antiproliferative principles. We have previously identified the
flavonoid quercetin‐3‐methyl ether (Q‐3‐ME) in an ethyl acetate fraction (EA). Both the …

Sesquiterpene lactones from Ambrosia spp. are active against a murine lymphoma cell line by inducing apoptosis and cell cycle arrest

R Martino, MF Beer, O Elso, O Donadel, V Sülsen… - Toxicology in Vitro, 2015 - Elsevier
Sesquiterpene lactones (STLs) are natural terpenoid compounds. They have been
recognized as antitumor agents. The purpose of this investigation was to explore the …