Chronic inflammation plays an important role in the development of metabolic diseases.
These include obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated fatty …

T-cell exhaustion was originally identified during chronic infection in mice, and was
subsequently observed in humans with cancer. The exhausted T cells in the tumor …

The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment
responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 …

Interleukin-1β (IL-1β) is abundant in the tumor microenvironment, where this cytokine can
promote tumor growth, but also antitumor activities. We studied IL-1β during early tumor …

The immune microenvironment is crucial for epithelial ovarian cancer (EOC) progression
and consists of tumor-associated macrophages (TAM) and T lymphocytes, such as …

Hepatocellular carcinoma (HCC) is one of the most aggressive types of cancer and lacks
effective therapeutic approaches. Most HCC develops in the setting of chronic liver injury …

Background–The presence of tumor-infiltrating lymphocytes (TILs) in the tumor
microenvironment is associated with an improved prognosis and a better response to …

The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

Pancreatic ductal adenocarcinoma (PDAC) is considered a “nonimmunogenic” neoplasm.
Single-agent immunotherapies have failed to demonstrate significant clinical activity in …

T cell senescence has been recognized to play an immunosuppressive role in the aging
population and cancer patients. Strategies dedicated to preventing or reversing replicative …