Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in
intercellular communication. The components of exosomes, including proteins, DNA, mRNA …

Currently, particular interest among the scientific community is focused on exploring the use
of exosomes for several pharmaceutical and biomedical applications. This is due to the …

Abstract CD133 (prominin-1), a pentaspan membrane glycoprotein, is one of the most well-
characterized biomarkers used for the isolation of cancer stem cells (CSCs). The presence …

Due to its multiple features, including the ability to orchestrate remote communication
between different tissues, the exosomes are the extracellular vesicles arousing the highest …

Mutations in IDH1 and IDH2 (encoding isocitrate dehydrogenase 1 and 2) drive the
development of gliomas and other human malignancies. Mutant IDH1 induces epigenetic …

The release of circulating tumor cells (CTCs) into vasculature is an early event in the
metastatic process. The analysis of CTCs in patients has recently received widespread …

Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are
characterized by a high metabolic plasticity resulting from mutations and the selection of …

Liquid biopsy is an emerging technology with a potential role in the screening and early
detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and …

Currently, gliomas are diagnosed by neuroimaging, and refined diagnosis requires
resection or biopsy to obtain tumour tissue for histopathological classification and grading …

Cancer stem cells (CSCs) are a subpopulation of neoplastic cells with self-renewal capacity
and limitless proliferative potential as well as high invasion and migration capacity. These …