Ethnopharmacological relevance Ginkgo biloba L.(Ginkgoaceae) is a treasure species with
high medicinal value. The Ming Dynasty “Compendium of Materia Medica” and Qing …

Abstract Background Ginkgo biloba L.(Ginkgoaceae), known as a" living fossil," has a long
history of medicinal use. Both its leaves and nuts have been widely prescribed for the …

Abstract Carboxylesterase 2 (CES2) is a serine-type hydrolase that plays important roles in
xenobiotic detoxification and lipid metabolism. Its abnormal expression is highly associated …

Background: Flavonoid class phytochemicals are natural compounds present in different
medicinal plants, vegetables and fruits. Ginkgo biloba contains significant amounts of …

Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …

Abstract Human carboxylesterase 2A (hCES2A) is a key serine hydrolase responsible for
the metabolic clearance of large number of compounds bearing the ester-or amide-bond (s) …

As the primary enzyme responsible for the activatable conversion of Irinotecan (CPT-11) to
SN-38, carboxylesterase 2 (CES2) is a significant predictive biomarker toward CPT-11 …

Gut bacterial β-glucuronidases (GUS) play an important role in deconjugation of various O-
glucuronides, which are tightly linked with the drug-induced intestinal toxicity. Increasing …

Background Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease, the incidence
of which increases annually. Shugan Xiaozhi (SGXZ) decoction, a composite traditional …

Obesity is one of the foremost public health concerns. Human pancreatic lipase (hPL), a
crucial digestive enzyme responsible for the digestion of dietary lipids in humans, has been …