Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review
current perspectives on the neural systems that regulate sleep/wake states in mammals and …

Sleep is a fundamental biological process observed widely in the animal kingdom, but the
neural circuits generating sleep remain poorly understood. Understanding the brain …

INTRODUCTION Sleep homeostasis, the balance between the duration of sleep and
wakefulness, is a fundamental feature of the sleep-wake cycle. During wakefulness, sleep …

Sleep is an essential process that supports learning and memory by acting on synapses
through poorly understood molecular mechanisms. Using biochemistry, proteomics, and …

Animal behavior was classically considered to be determined exclusively by neuronal
activity, whereas surrounding glial cells such as astrocytes played only supportive roles …

The immunosuppressive effect of adenosine in the microenvironment of a tumor is well
established. Presently, researchers are developing approaches in immune therapy that …

Mammalian sleep expression and regulation have historically been thought to reflect the
activity of neurons. Changes in other brain cells (glia) across the sleep-wake cycle and their …

The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …

Sleep disorders have received widespread attention nowadays, which have been promoted
by the accelerated pace of life, unhealthy diets and lack of exercise in modern society. The …

Sleep is a vital and evolutionarily conserved process, critical to daily functioning and
homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental …