Radiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract
disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear …

Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …

Lung organoids display a tissue-specific functional phenomenon and mimic the features of
the original organ. They can reflect the properties of the cells, such as morphology, polarity …

Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the
gastrointestinal tract, including Crohn's disease, ulcerative colitis and inflammatory bowel …

Interstitial lung diseases (ILDs) in adults and children (chILD) are a heterogeneous group of
lung disorders leading to inflammation, abnormal tissue repair and scarring of the lung …

The lung is regarded as having limited regenerative capacity, and there are few treatment
options for refractory lung diseases, such as interstitial pneumonia. Lung transplantation is …

Genetic toxicology, strategically located at the intersection of genetics and toxicology, aims
to demystify the complex interplay between exogenous agents and our genetic blueprint …

Although mechanisms of telomere protection are well-defined in differentiated cells, it is
poorly understood how stem cells sense and respond to telomere dysfunction. In particular …

Neonatal lung and heart diseases, albeit rare, can result in poor quality of life, often require
long-term management and/or organ transplantation. For example, Congenital Heart …

Telomeres protect chromosome ends and determine the replication potential of dividing
cells. The canonical telomere sequence TTAGGG is synthesized by telomerase …