Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

It has long been hypothesized that conditioning mechanisms play major roles in addiction.
Specifically, the associations between rewarding properties of drugs of abuse and the drug …

Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from
numerous subunit combinations that compose channel-receptor complexes with varied …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion
channels which are widely distributed in the human brain. Multiple subtypes of these …

Rationale Nicotine has been shown in a variety of studies in humans and experimental
animals to improve cognitive function. Nicotinic treatments are being developed as …

The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Nicotine and other nicotinic agonists have been found to improve performance on attention
and memory tasks. Clinical studies using nicotine skin patches have demonstrated the …

Nicotinic cholinergic systems are involved with several important aspects of cognitive
function including attention, learning and memory. Nicotinic cholinergic receptors are …