Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …

Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …

Luminescent semiconductor quantum dots (QDs) are one of the more popular nanomaterials
currently utilized within biological applications. However, what is not widely appreciated is …

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that
involve G-quartets linked by loop nucleotides. The structural and topological diversity of G …

Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-
quadruplexes. These structures may be very stable under physiological conditions …

Because RNA lacks strong intrinsic fluorescence, it has proven challenging to track RNA
molecules in real time. To address this problem and to allow the purification of fluorescently …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

Thioflavin T (ThT) becomes fluorescent in the presence of the G-quadruplex structure such
as that formed by the human telomeric motif. In this report, we extend and generalize these …

The structural diversity and functional relevance of nucleic acids (NAs), mainly
deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all …