Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …

The seminal paper on the CYP2D6 Activity Score (AS) was first published ten years ago
and, since its introduction in 2008, it has been widely accepted in the field of …

Introduction: The frequency of CYP2D6 alleles, related to either a lack of or increased
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …

Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

Pharmacogenomics (PGx) has a growing impact on healthcare and constitutes one of the
major pillars of personalised medicine. For the purpose of improved individualised drug …

Both safety and efficacy of medical treatment can vary depending on the ethnogeographic
background of the patient. One of the reasons underlying this variability is differences in …

Abstract Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier
for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was …

Aim: The purpose of this study was to determine the genetic polymorphisms of the CYP2D6
gene and to elucidate the allele distribution pattern in the Chinese Han population. Materials …

Wild type genotypes (CYP2D6) and their allelic variants have been described in a sample of
a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6* 3 and …

Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing
enzymes confer substantial person-to-person and between-population differences in …