A handful of biological proton-selective ion channels exist. Some open at positive or
negative membrane potentials, others open at low or high pH, and some are light activated …

With a single gene encoding HV1 channel, proton channel diversity is particularly low in
mammals compared to other members of the superfamily of voltage-gated ion channels …

Aims Epicardium and epicardium-derived cells are critical players in myocardial fibrosis.
Mesenchymal stem cell–derived extracellular vesicles (EVs) have been studied for cardiac …

Although the precise mechanisms determining the neurotoxic or neuroprotective activation
phenotypes in microglia remain poorly characterized, metabolic changes in these cells …

Voltage-dependent gating of the voltage-gated proton channels (HV 1) remains poorly
understood, partly because of the difficulty of obtaining direct measurements of voltage …

In voltage-gated Na+ and K+ channels, the hydrophobicity of non-charged residues in the
S4 helix has been shown to regulate the S4 movement underlying the process of voltage …

Myeloid-derived suppressor cells (MDSCs) are key determinants of the immunosuppressive
microenvironment in tumors. As ion channels play key roles in the physiology …

The voltage-gated proton channel H v 1 is a member of voltage-gated ion channels
containing voltage-sensing domains (VSDs). The VSDs are made of four membrane …

Unlike other members of the voltage-gated ion channel superfamily, voltage-gated proton
(Hv) channels are solely composed of voltage sensor domains without separate ion …

5-chloro-2-guanidinobenzimidazole (ClGBI), a small-molecule guanidine derivative, is a
known effective inhibitor of the voltage-gated proton (H+) channel (HV1, Kd≈ 26 μM) and is …