Cascade synthetic strategies opening access to medicinal-relevant aliphatic 3-and 4-membered N-heterocyclic scaffolds

D Łowicki, P Przybylski - European Journal of Medicinal Chemistry, 2022 - Elsevier
Cascade reactions are often 'employed'by nature to construct structurally diverse nitrogen-
containing heterocycles in a highly stereoselective fashion, ie, secondary metabolites …

Green synthesis of silver nanoformulation of Scindapsus officinalis as potent anticancer and predicted anticovid alternative: Exploration via experimental and …

M Pathak, P Pathak, H Khalilullah, M Grishina… - Biocatalysis and …, 2021 - Elsevier
The current study was focused on the investigation of anticancer activity of Scindapsus
Officinalis fruit extract embedded silver nanoparticles (So-AgNPs) followed by anticovid …

Cucumis melo var. momordica as a Potent Antidiabetic, Antioxidant and Possible Anticovid Alternative: Investigation through Experimental and Computational …

JP Yadav, M Grishina, M Shahbaaz… - Chemistry & …, 2022 - Wiley Online Library
Diabetes mellitus is a typical life threatening of disease, which generate due to the
dysfunction of β cells of pancreas. In 2014, WHO stated that 422 million people were …

[HTML][HTML] β-Lactams and Ureas as Cross Inhibitors of Prokaryotic Systems

MI Konaklieva, BJ Plotkin - Applied Microbiology, 2023 - mdpi.com
β-Lactams in the last thirty years have been viewed as universal acylating agents of serine
and cysteine enzymes of both prokaryotic and eukaryotic systems. More recently, their use …

Synthesis of benzo [f][1, 2] thiazepine 1, 1-dioxides based on the visible-light-mediated aza Paternò–Büchi reaction of benzo [d] isothiazole 1, 1-dioxides with alkenes

YL Wang, PX Liu, HH Zhang, PF Xu… - Chemical …, 2023 - pubs.rsc.org
A new two-step, one-pot synthesis of benzo [f][1, 2] thiazepine 1, 1-dioxides was developed,
which contains a visible-light mediated aza Paternò–Büchi reaction of benzo [d] isothiazole …

[HTML][HTML] Effective inhibition of HCoV-OC43 and SARS-CoV-2 by phytochemicals in vitro and in vivo

D Ojha, F Jessop, CM Bosio, KE Peterson - International Journal of …, 2023 - Elsevier
Objective Several coronaviruses, including severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and human coronavirus OC43 (HCoV-OC43), can cause respiratory …

Heterocyclic Scaffolds in Novel Synthetic Antibacterial Agents

BK Tiwary, K Pradhan - Alternatives to Antibiotics: Recent Trends and …, 2022 - Springer
The emergence of antibiotic resistant bacteria is becoming a serious global problem. The
situation will look very grim in the near future if proper strategies for tackling this menace are …

Synthesis and characterization of 2-pyrone compounds derived from coumalic acid and evaluation of the antimicrobial activity of some of them

MS Noory, MS Hussein - AIP Conference Proceedings, 2023 - pubs.aip.org
This work included the preparation of compounds containing 2-pyrone rings starting from
self-condensation of two molecules of malic acid to obtain coumalic acid MS1, which reacts …

Synthesis of 2-Azetidinones via Cycloaddition Approaches: An Update

FM Cordero, D Giomi, F Machetti - 2024 - preprints.org
The present review is a comprehensive update of the synthesis of monocyclic β-lactams via
cycloaddition reactions. According to the IUPAC definition of cycloaddition, both elementary …

Four-membered ring systems

J Anaya, RM Sánchez - Progress in Heterocyclic Chemistry, 2021 - Elsevier
This chapter covers work published in the calendar year 2020. The synthesis and reactivity
of four-membered heteroatom-containing cycles are reviewed. New developments in the …