Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements

RM Dorrian, CF Berryman, A Lauto… - Frontiers in Cellular …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory
and autonomic functions. Additionally, many individuals experience chronic neuropathic …

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

[HTML][HTML] Generation of direct current electrical fields as regenerative therapy for spinal cord injury: A review

L Matter, B Harland, B Raos, D Svirskis… - APL bioengineering, 2023 - pubs.aip.org
Electrical stimulation (ES) shows promise as a therapy to promote recovery and
regeneration after spinal cord injury. ES therapy establishes beneficial electric fields (EFs) …

Schwann cell-derived exosomal vesicles: a promising therapy for the injured spinal cord

M Ghosh, DD Pearse - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular
milieu. Within these nanovesicles reside a multitude of bioactive molecules, which …

[HTML][HTML] Sensory-motor coupling electrical stimulation driven by a bionic Z‐structured triboelectric nanogenerator improves functional recovery from spinal cord injury

B Lu, S Jia, Z Wang, W Wu, L Yan, L Zhu, D Hao - Nano Energy, 2023 - Elsevier
Spinal cord injury (SCI) disrupts the neuronal relay circuits and causes limb paralysis.
Although epidural electrical stimulation is a therapeutic approach for SCI, electrical …

Rehabilitation training after spinal cord injury affects brain structure and function: From mechanisms to methods

LW He, XJ Guo, C Zhao, JS Rao - Biomedicines, 2023 - mdpi.com
Spinal cord injury (SCI) is a serious neurological insult that disrupts the ascending and
descending neural pathways between the peripheral nerves and the brain, leading to not …

Research progress on the application of transcranial magnetic stimulation in spinal cord injury rehabilitation: a narrative review

Y Wang, T Dong, X Li, H Zhao, L Yang, R Xu… - Frontiers in …, 2023 - frontiersin.org
Traumatic or non-traumatic spinal cord injury (SCI) can lead to severe disability and
complications. The incidence of SCI is high, and the rehabilitation cycle is long, which …

[HTML][HTML] Established and emerging therapies in acute spinal cord injury

R Gadot, DN Smith, M Prablek, JK Grochmal… - Neurospine, 2022 - ncbi.nlm.nih.gov
Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an
annual incidence of 20–50 per million people. Following initial assessment with appropriate …

Downregulation of EphB2 by RNA interference attenuates glial/fibrotic scar formation and promotes axon growth

J Wu, ZY Zhu, ZW Fan, Y Chen… - Neural Regeneration …, 2022 - journals.lww.com
The rapid formation of a glial/fibrotic scar is one of the main factors hampering axon growth
after spinal cord injury. The bidirectional EphB2/ephrin-B2 signaling of the fibroblast …