Introduction 3. NO and endothelium-dependent hyperpolarizations 3.1. EDHF-mediated,
endothelium-dependent relaxations 3.2. NO and EDHF-mediated responses 3.2. 1. NO and …

Synthetic peptides homologous to the extracellular loops of the major vascular connexins
represent a novel class of gap junction blockers that have been used to assess the role of …

Gap junctions and their connexin components are indispensable in mediating the cellular
coordination required for tissue and organ homeostasis. The critical nature of their existence …

The advances made in vascular biology in the last 25 years have considerably changed the
perception that one could have of the endothelial cells. Once considered as a diffusion …

In the rat hepatic artery, the endothelium‐derived hyperpolarizing factor (EDHF) was
identified as potassium. Potassium hyperpolarizes the smooth muscles by gating inward …

In the endothelium, ATP-sensitive potassium (KATP) channels are thought to couple cellular
metabolism with membrane excitability, calcium entry, and endothelial mediator release. We …

Abstract Alterations in Connexin43 (Cx43) expression levels have been shown to play a role
in inflammatory processes including skin wounding and neuroinflammation. Cx43 protein …

Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination
of cells in the vascular wall. However, little is known about their physiological regulation in …

Gap junctions interconnect vascular cells homocellularly, thereby allowing the spread of
signals along the vessel wall, which serve to coordinate vessel behavior. In addition, gap …

Epileptic seizures typically result in delayed neuronal loss secondary to the initial damage
and an up-regulation in connexin43 (Cx43). This study investigated the role of Cx43 gap …