Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Genetically or surgically altered mice are commonly used as models of human
cardiovascular diseases. Electrocardiography (ECG) is the gold standard to assess cardiac …

Aging is a major risk factor for impaired cardiovascular health. Because the aging
myocardium is characterized by microcirculatory dysfunction, and because nerves align with …

Age is a major risk factor for the development of cardiovascular diseases in men and in
women. However, not all people age at the same rate and those who are aging rapidly are …

The combined influences of sinoatrial nodal (SAN) pacemaker cell automaticity and its
response to autonomic input determine the heart's beating interval variability and mean …

Average beat interval (BI) and beat interval variability (BIV) are primarily determined by
mutual entrainment between the autonomic-nervous system (ANS) and intrinsic …

Nonlinear analyses of heart rate variability (HRV) can be used to quantify the
unpredictability, fractal properties and complexity of heart rate. Fractality and its analysis …

Heart rate (HR) is controlled by the sinoatrial node (SAN). SAN dysfunction is highly
prevalent in aging; however, not all individuals age at the same rate. Rather, health status …

Advanced age is an independent risk factor for cardiovascular diseases in both sexes. This
is thought to be due, in part, to age-dependent cellular, structural, and functional changes in …

Aging is a major risk factor for sinoatrial node (SAN) dysfunction, which can impair heart rate
(HR) control and heart rate variability (HRV). HR and HRV are determined by intrinsic SAN …