[HTML][HTML] Exploring the impact of obesity on skeletal muscle function in older age

PT Morgan, B Smeuninx, L Breen - Frontiers in Nutrition, 2020 - frontiersin.org
Sarcopenia is of important clinical relevance for loss of independence in older adults. The
prevalence of obesity in combination with sarcopenia ('sarcopenic-obesity') is increasing at …

[HTML][HTML] Age-related skeletal muscle dysfunction is aggravated by obesity: an investigation of contractile function, implications and treatment

J Tallis, S Shelley, H Degens, C Hill - Biomolecules, 2021 - mdpi.com
Obesity is a global epidemic and coupled with the unprecedented growth of the world's older
adult population, a growing number of individuals are both old and obese. Whilst both …

Luteolin Protects Against Obese Sarcopenia in Mice with High‐Fat Diet‐Induced Obesity by Ameliorating Inflammation and Protein Degradation in Muscles

JW Kim, SK Shin, EY Kwon - Molecular Nutrition & Food …, 2023 - Wiley Online Library
Scope Although sarcopenia is mainly caused by aging, sarcopenia due to obesity has
become an emerging issue given the increase in obesity among people of various ages …

[HTML][HTML] Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding

PJ Ferrara, ARP Verkerke, JA Maschek… - … : official publication of …, 2021 - ncbi.nlm.nih.gov
Obesity alters skeletal muscle lipidome and promotes myopathy, but it is unknown whether
aberrant muscle lipidome contributes to the reduction in skeletal muscle contractile force …

[HTML][HTML] Deleterious effect of high-fat diet on skeletal muscle performance is prevented by high-protein intake in adult rats but not in old rats

E Poggiogalle, F Rossignon, A Carayon… - Frontiers in …, 2022 - frontiersin.org
The phenotype of sarcopenic obesity is frequently associated with impaired muscle strength
and performance. Ectopic lipid deposition may interfere with muscle anabolic response …

Current perspectives on obesity and skeletal muscle contractile function in older adults

CR Straight, MJ Toth, MS Miller - Journal of Applied …, 2021 - journals.physiology.org
Obesity has become one of the most pressing public health issues of the 21st century and
currently affects a substantial proportion of the older adult population. Although the …

[HTML][HTML] Influence of obesity and type 2 diabetes on calcium handling by skeletal muscle: spotlight on the sarcoplasmic reticulum and mitochondria

H Eshima - Frontiers in Physiology, 2021 - frontiersin.org
Obesity and diabetes have been shown to interfere with energy metabolism and cause
peripheral insulin resistance in skeletal muscle. However, recent studies have focused on …

Relative contribution of neuromuscular activation, muscle size, and muscle quality to maximum strength output of the thigh muscles in young individuals

A Yoshiko, K Watanabe, H Akima - Physiological Reports, 2023 - Wiley Online Library
This study aimed to investigate the relationship between maximal muscle strength and
neuromuscular activation, muscle size, and quality of quadriceps (QF) and hamstring …

High‐fat diet effects on contractile performance of isolated mouse soleus and extensor digitorum longus when supplemented with high dose vitamin D

SP Shelley, RS James, SJ Eustace… - Experimental …, 2024 - Wiley Online Library
Evidence suggests vitamin D3 (VD) supplementation can reduce accumulation of adipose
tissue and inflammation and promote myogenesis in obese individuals, and thus could …

[HTML][HTML] Understanding altered contractile properties in advanced age: insights from a systematic muscle modelling approach

DL Mayfield, NJ Cronin, GA Lichtwark - Biomechanics and Modeling in …, 2023 - Springer
Age-related alterations of skeletal muscle are numerous and present inconsistently, and the
effect of their interaction on contractile performance can be nonintuitive. Hill-type muscle …