[HTML][HTML] Advances and perspective on animal models and hydrogel biomaterials for diabetic wound healing

Y Hu, Y Xiong, R Tao, H Xue, L Chen, Z Lin… - Biomaterials …, 2022 - ncbi.nlm.nih.gov
Diabetic wounds are a common complication in diabetes patients. Due to peripheral nerve
damage and vascular dysfunction, diabetic wounds are prone to progress to local ulcers …

Single cell analyses reveal specific distribution of anti‐bacterial molecule Perforin‐2 in human skin and its modulation by wounding and Staphylococcus aureus …

N Strbo, I Pastar, L Romero, V Chen… - Experimental …, 2019 - Wiley Online Library
Abstract Perforin‐2 (P‐2) is a recently described antimicrobial protein with unique properties
to kill intracellular bacteria. We investigated P‐2 expression pattern and cellular distribution …

A tractable, simplified ex vivo human skin model of wound infection

DJ Yoon, DR Fregoso, D Nguyen… - Wound Repair and …, 2019 - Wiley Online Library
The prevalence of infection in chronic wounds is well documented in the literature but not
optimally studied due to the drawbacks of current methodologies. Here, we describe a …

[HTML][HTML] A comprehensive review on function of miR-15b-5p in malignant and non-malignant disorders

S Ghafouri-Fard, T Khoshbakht, BM Hussen… - Frontiers in …, 2022 - frontiersin.org
miR-15b-5p is encoded by MIR15B gene. This gene is located on cytogenetic band 3q25.
33. This miRNA participates in the pathogenesis of several cancers as well as non …

[HTML][HTML] Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds

AL Lauterbach, RP Wallace, AT Alpar… - NPJ Regenerative …, 2023 - nature.com
Non-healing wounds have a negative impact on quality of life and account for many cases of
amputation and even early death among patients. Diabetic patients are the predominate …

Identification of hub genes and pathways associated with cellular senescence in diabetic foot ulcers via comprehensive transcriptome analysis

Y Huang, D Wang, W Zhang, X Yuan… - Journal of Cellular …, 2024 - Wiley Online Library
This research aimed to find important genes and pathways related to cellular senescence
(CS) in diabetic foot ulcers (DFU) and to estimate the possible pathways through which CS …

Identification and verification of ferroptosis‐related genes in diabetic foot using bioinformatics analysis

X Wang, S Dai, W Zheng, W Chen, J Li… - International Wound …, 2023 - Wiley Online Library
Ferroptosis is a novel form of cell death that plays a key role in several diseases, including
inflammation and tumours; however, the role of ferroptosis‐related genes in diabetic foot …

Protecting human amnion and chorion matrices during processing: Performance enhancement in a diabetic mouse model and human co‐culture system

MC Sanders, S Balaji, WB Martin… - Wound Repair and …, 2023 - Wiley Online Library
Recent evidence suggests that protecting human amnion and chorion matrices (HACM)
during processing enhances the performance of HACM for wound repair and tissue …

Cellular reprogramming of diabetic foot ulcer fibroblasts triggers pro‐healing miRNA‐mediated epigenetic signature

I Pastar, J Marjanovic, L Liang, RC Stone… - Experimental …, 2021 - Wiley Online Library
Diabetic foot ulcers (DFUs), a prevalent complication of diabetes, constitute a major medical
challenge with a critical need for development of cell‐based therapies. We previously …

[HTML][HTML] Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression Analysis

AM Elsherbini, AM Alsamman, NM Elsherbiny… - International Journal of …, 2022 - mdpi.com
The molecular basis of diabetes mellitus is yet to be fully elucidated. We aimed to identify the
most frequently reported and differential expressed genes (DEGs) in diabetes by using …