Brugada syndrome is a rare, inherited cardiac disease leading to ventricular fibrillation and
sudden cardiac death in structurally normal hearts. Clinical diagnosis requires a Brugada …

The prevalence and economic burden of atrial fibrillation (AF) are predicted to more than
double over the next few decades. In addition to anticoagulation and treatment of …

Objectives: Atrial fibrillation has been associated with increased mortality in critically ill
patients. We sought to determine whether atrial fibrillation in the ICU is an independent risk …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a major cause of
stroke and morbidity. The strongest genetic risk factors for AF in humans are variants on …

Human induced pluripotent stem cell (hiPSC)-derived atrial cardiomyocytes (CMs) hold
great promise for elucidating underlying cellular mechanisms that cause atrial fibrillation …

Background: Postoperative atrial fibrillation (PoAF) remains a significant risk factor for
increased morbidity and mortality after cardiac surgery. The ability to accurately identify …

Background Genomewide association studies have identified several loci associated with
atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation …

Aims To test the hypothesis that vulnerability to atrial fibrillation (AF) is associated with rare
coding sequence variation in the SCN10A gene, which encodes the voltage-gated sodium …

Mutations in SCN5A, encoding the cardiac sodium channel, are linked with familial atrial
fibrillation (AF) but the underlying pathophysiologic mechanisms and implications for …

Background Atrial fibrillation (AF) is the most common cardiac arrhythmia. Currently, 14
genes important for ion channel function, intercellular signaling, and homeostatic control …