Therapeutic targeting of NF-κB in acute lung injury: a double-edged sword
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …
[PDF][PDF] Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis
J May, JA Mitchell, RG Jenkins - Journal of Clinical …, 2023 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with poor
survival. The incidence and mortality of IPF are rising, but treatment remains limited …
survival. The incidence and mortality of IPF are rising, but treatment remains limited …
Vascular smooth muscle cell dysfunction in neurodegeneration
Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics
in response to the brain's oxygen and nutrient demands. Crucially, VSMCs may provide a …
in response to the brain's oxygen and nutrient demands. Crucially, VSMCs may provide a …
[HTML][HTML] Comprehensive review on novel targets and emerging therapeutic modalities for pulmonary arterial Hypertension
Abstract Pulmonary Arterial Hypertension (PAH) is the progressive increase in mean
pulmonary arterial pressure (mPAP)(≥ 20 mmHg at rest). Current treatment strategies …
pulmonary arterial pressure (mPAP)(≥ 20 mmHg at rest). Current treatment strategies …
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
Cardiovascular disease (CVD) continues to be the primary cause of global mortality.
Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and …
Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and …
[HTML][HTML] Mechanistic and therapeutic perspectives of baicalin and baicalein on pulmonary hypertension: A comprehensive review
L Cui, T Yuan, Z Zeng, D Liu, C Liu, J Guo… - Biomedicine & …, 2022 - Elsevier
Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic
drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds …
drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds …
Nanomedicine-mediated therapeutic approaches for pulmonary arterial hypertension
E Mirhadi, P Kesharwani, TP Johnston… - Drug Discovery Today, 2023 - Elsevier
Highlights•Nanomedicine has emerged as a field with great opportunities to improve
treatment strategies.•Pulmonary arterial hypertension (PAH) is a serious and incurable …
treatment strategies.•Pulmonary arterial hypertension (PAH) is a serious and incurable …
Rutin Inhibits the Progression of Osteoarthritis Through CBS-Mediated RhoA/ROCK Signaling
C Sui, Y Wu, R Zhang, T Zhang, Y Zhang, J Xi… - DNA and Cell …, 2022 - liebertpub.com
Osteoarthritis (OA) is a chronic joint disease characterized by the deterioration of cartilage
and subchondral bone in the joints. Currently, there is no complete cure for OA, only …
and subchondral bone in the joints. Currently, there is no complete cure for OA, only …
Divergent roles of ephrin-B2/EphB4 guidance system in pulmonary hypertension
S Crnkovic, S Rittchen, K Jandl, J Gindlhuber… - …, 2023 - Am Heart Assoc
Background: Smooth muscle cell (SMC) expansion is one key morphological hallmark of
pathologically altered vasculature and a characteristic feature of pulmonary vascular …
pathologically altered vasculature and a characteristic feature of pulmonary vascular …
Investigating the Anticancer Activity of G-Rh1 Using In Silico and In Vitro Studies (A549 Lung Cancer Cells)
Ginsenoside Rh1 (G-Rh1), a possible bioactive substance isolated from the Korean Panax
ginseng Meyer, has a wide range of pharmacological effects. In this study, we have …
ginseng Meyer, has a wide range of pharmacological effects. In this study, we have …