Reduced nicotinamide adenine dinucleotide, NADH, is a major electron donor in the
oxidative phosphorylation and glycolytic pathways in cells. As a result, there has been …

Fluorescence lifetime imaging microscopy (FLIM) is increasingly used in biomedicine,
material science, chemistry, and other related research fields, because of its advantages of …

Regional metastasis of head and neck cancer (HNC) is prevalent (approximately 50% of
patients at diagnosis), yet the underlying drivers and mechanisms of lymphatic spread …

Application of two-photon microscopy (TPM) to translational and clinical cancer research
has burgeoned over the last several years, as several avenues of pre-clinical research have …

Second‐harmonic generation (SHG) microscopy is a fantastic tool for imaging collagen and
probing its hierarchical organization from molecular scale up to tissue architectural level. In …

Two-photon imaging of endogenous fluorescence can provide physiological and metabolic
information from intact tissues. However, simultaneous imaging of multiple intrinsic …

Integrating biological imaging into early stages of the drug discovery process can provide
invaluable readouts of drug activity within complex disease settings, such as cancer …

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool to quantify molecular
compositions and study molecular states in complex cellular environment as the lifetime …

Abstract While NAD (P) H fluorescence lifetime imaging (FLIM) can detect changes in flux
through the TCA cycle and electron transport chain (ETC), it remains unclear whether NAD …

Molecular imaging has rapidly emerged as a discipline with the potential to impact
fundamental biomedical research and clinical practice. Within this field, optical imaging …