Cysteine cathepsins as therapeutic targets in immune regulation and immune disorders
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …
role in several processes—such as protein degradation, changes in cell signaling, cell …
LAG-3 as a potent target for novel anticancer therapies of a wide range of tumors
LAG-3 (Lymphocyte activation gene 3) protein is a checkpoint receptor that interacts with
LSEC-tin, Galectin-3 and FGL1. This interaction leads to reduced production of IL-2 and IFN …
LSEC-tin, Galectin-3 and FGL1. This interaction leads to reduced production of IL-2 and IFN …
Mendelian randomization analyses explore the relationship between cathepsins and lung cancer
J Li, M Tang, X Gao, S Tian, W Liu - Communications biology, 2023 - nature.com
Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex
pathogenesis. Cathepsins, lysosomal cysteine proteases, play roles in various physiological …
pathogenesis. Cathepsins, lysosomal cysteine proteases, play roles in various physiological …
Glycosylated cathepsin V serves as a prognostic marker in lung cancer
L Yang, Q Zeng, Y Deng, Y Qiu, W Yao, Y Liao - Frontiers in Oncology, 2022 - frontiersin.org
Dysregulation of cysteine cathepsin protease activity is pivotal in tumorigenic transformation.
However, the role of cathepsin protease in lung cancer remains unknown. Here, we …
However, the role of cathepsin protease in lung cancer remains unknown. Here, we …
Down regulation of Cathepsin W is associated with poor prognosis in pancreatic cancer
F Khojasteh-Leylakoohi, R Mohit, N Khalili-Tanha… - Scientific reports, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis.
Therefore, there has been a focus on identifying new biomarkers for its early diagnosis and …
Therefore, there has been a focus on identifying new biomarkers for its early diagnosis and …
ZEPPI: Proteome-scale sequence-based evaluation of protein–protein interaction models
We introduce ZEPPI (Z-score Evaluation of Protein–Protein Interfaces), a framework to
evaluate structural models of a complex based on sequence coevolution and conservation …
evaluate structural models of a complex based on sequence coevolution and conservation …
Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets
K Zdravkova, O Mijanovic, A Brankovic, PM Ilicheva… - Cells, 2024 - mdpi.com
Cysteine cathepsins F and W are members of the papain-like cysteine protease family,
which have distinct structural features and functional roles in various physiological and …
which have distinct structural features and functional roles in various physiological and …
Reduced expression of cathepsin F predicts poor prognosis in patients with clear cell renal cell carcinoma
X Zhou, H Chen, D Huang, G Guan, X Ma, W Cai… - Scientific Reports, 2024 - nature.com
Abnormalities in the extracellular matrix (ECM) play important roles in the regulation and
progression of clear cell renal cell carcinoma (ccRCC). The cysteine cathepsin is one of the …
progression of clear cell renal cell carcinoma (ccRCC). The cysteine cathepsin is one of the …
[HTML][HTML] ALAS2 overexpression alleviates oxidative stress-induced ferroptosis in aortic aneurysms via GATA1 activation
Y He, X Wang, D Li, Q Zhu, Y Xiang, Y He… - Journal of Thoracic …, 2024 - ncbi.nlm.nih.gov
Background Aortic aneurysm, characterized by abnormal dilation of the aorta, poses
significant health risks. This study aims to investigate the interaction between 5 …
significant health risks. This study aims to investigate the interaction between 5 …
转录因子MYB 激活CTSF 通过谷氨酰胺代谢影响胃癌细胞增殖和细胞干性.
胡明亮， 王强 - Journal of China Medical University, 2024 - search.ebscohost.com
摘要目的探讨转录因子MYB 激活组织蛋白酶F (CTSF) 通过谷氨酰胺代谢对胃癌细胞增殖和干
性的影响及其作用机制. 方法通过癌症基因组图谱(TCGA) 数据库分析CTSF …
性的影响及其作用机制. 方法通过癌症基因组图谱(TCGA) 数据库分析CTSF …