Sex differences in cancer mechanisms

JB Rubin, JS Lagas, L Broestl, J Sponagel… - Biology of sex …, 2020 - Springer
We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Vascular endothelial growth factor (VEGF), mast cells and inflammation

YB Shaik-Dasthagirisaheb, G Varvara… - International journal …, 2013 - journals.sagepub.com
Vascular endothelial growth factor (VEGF) is one of the most important inducers of
angiogenesis, therefore blocking angiogenesis has led to great promise in the treatment of …

Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation

MJ Hsieh, HT Liu, CN Wang, HY Huang, Y Lin… - Journal of Molecular …, 2017 - Springer
BPC 157, a pentadecapeptide with extensive healing effects, has recently been suggested
to contribute to angiogenesis. However, the underlying mechanism is not yet clear. The …

Role of VEGF-A in angiogenesis promoted by umbilical cord-derived mesenchymal stromal/stem cells: in vitro study

I Arutyunyan, T Fatkhudinov, E Kananykhina… - Stem Cell Research & …, 2016 - Springer
Background Mesenchymal stromal/stem cells derived from human umbilical cord (UC-
MSCs) uniquely combine properties of embryonic and postnatal MSCs and may be the most …

VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways

JC Weddell, S Chen, PI Imoukhuede - NPJ systems biology and …, 2017 - nature.com
The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …

Smartly engineered casein manganese oxide nanobiomaterials and its potential therapeutic angiogenesis applications for wound healing and limb ischemia

S Haque, R Kotcherlakota, P Bhamidipati… - Advanced …, 2023 - Wiley Online Library
Recent research offers several approaches for the advancement of manganese‐based
nanomaterials for its therapeutic use. The present research paper reports the development …

[HTML][HTML] Beyond CFD: Emerging methodologies for predictive simulation in cardiovascular health and disease

EL Schwarz, L Pegolotti, MR Pfaller… - Biophysics Reviews, 2023 - pubs.aip.org
Physics-based computational models of the cardiovascular system are increasingly used to
simulate hemodynamics, tissue mechanics, and physiology in evolving healthy and …

Regulation of skeletal muscle capillary growth in exercise and disease

TL Haas, E Nwadozi - Applied Physiology, Nutrition, and …, 2015 - cdnsciencepub.com
Capillaries, which are the smallest and most abundant type of blood vessel, form the primary
site of gas, nutrient, and waste transfer between the vascular and tissue compartments …

Quantitative fluorescent profiling of VEGFR s reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts

PI Imoukhuede, AS Popel - Cancer medicine, 2014 - Wiley Online Library
Plasma membrane‐localized vascular endothelial growth factor receptors (VEGFR) play a
critical role in transducing VEGF signaling toward pro and antiangiogenic outcomes and …

Characterizing glioblastoma heterogeneity via single-cell receptor quantification

S Chen, T Le, BAC Harley… - Frontiers in bioengineering …, 2018 - frontiersin.org
Dysregulation of tyrosine kinase receptor (RTK) signaling pathways play important roles in
glioblastoma (GBM). However, therapies targeting these signaling pathways have not been …