Despite the physiological role of oxidant molecules, oxidative stress (OS) could underlie
several human diseases. When the levels of antioxidants are too low or too high, OS occurs …

Abstract Background Adverse outcome pathways (AOPs) are conceptual frameworks that
organize knowledge about biological interactions and toxicity mechanisms. They present a …

Oxidative stress is a significant factor in male infertility, compromising sperm function and
overall reproductive health. As male infertility garners increasing attention, effective …

Sperm selection in the female reproductive tract (FRT) is sophisticated. Only about 1,000
sperm out of millions in an ejaculate reach the fallopian tube and thus have a chance of …

Male reproductive function is highly susceptible to oxidative stress, which arises from an
imbalance between reactive oxygen species (ROS) production and antioxidant defense …

Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone
deacetylases, comprising seven members SIRT1-SIRT7. Sirtuins have been extensively …

Spermatogonial stem cells exhibit a low level of spontaneous mutation that is heavily
impacted by paternal age via mechanisms that appear to involve the aberrant repair of DNA …

Male infertility is a multifactorial condition influenced by epigenetic regulation, oxidative
stress, and mitochondrial dysfunction. Oxidative stress-induced damage leads to epigenetic …

Blood-testis barrier (BTB) damage promotes spermatogenesis dysfunction, which is a critical
cause of male infertility. Dyslipidemia has been correlated with male infertility, but the major …

The negative effect of advanced female age on fertility and offspring health is well
understood. In comparison, much less is known about the implications of male age on …