Invasive fungal infections pose an important threat to public health and are an under-
recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a …

Purpose Voriconazole, an antifungal drug, is metabolized by a cytochrome P450 isozyme.
Increased adverse effects are observed in Asians because of the high rate of poor …

Because of the high research and development cost of new drugs, the long development
process of new drugs, and the high failure rate at later stages, combining past drugs has …

Elexacaftor/tezacaftor/ivacaftor (ETI) treatment has potential benefits in lung transplant
recipients, including improvements in extrapulmonary manifestations, such as …

Piroxicam is a non-steroidal anti-inflammatory drug used to alleviate symptoms of
osteoarthritis and rheumatoid arthritis. CYP2C9 genetic polymorphism significantly …

Purpose For decades, inflammation has been considered a cause of pharmacokinetic
variability, mainly in relation to the inhibitory effect of pro-inflammatory cytokines on the …

Metoprolol, a selective β1-adrenoreceptor blocking agent used in the treatment of
hypertension, angina, and heart failure, is primarily metabolized by the CYP2D6 enzyme …

Invasive fungal infections increase mortality and morbidity rates worldwide. The treatment of
these infections is still limited due to the low bioavailability and toxicity, requiring therapeutic …

Abstract Tamsulosin, a selective\upalpha _ 1 α 1-adrenoceptor blocker, is commonly used
for alleviation of lower urinary tract symptoms related to benign prostatic hyperplasia …

Cytochrome P450 3A4 (CYP3A4) is one of the major drug metabolizing enzymes in the
human body and metabolizes∼ 30–50% of clinically used drugs. Inhibition of CYP3A4 must …