Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Congenital stationary night blindness (CSNB) refers to a group of genetically and clinically
heterogeneous retinal disorders. Seventeen different genes with more than 360 different …

Background Calcium ions are involved in several human cellular processes including
corticogenesis, transcription, and synaptogenesis. Nevertheless, the relationship between …

Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …

Abstract α 2 δ proteins are membrane-anchored extracellular glycoproteins which are
abundantly expressed in the brain and the peripheral nervous system. They serve as …

α2δ-4 is an auxiliary subunit of voltage-gated Cav1. 4 L-type channels that regulate the
development and mature exocytotic function of the photoreceptor ribbon synapse. In …

The mammalian retina is the most unique tissue among those that display robust
circadian/diurnal oscillations. The retina is not only a light sensing tissue that relays light …

In nerve cells the genes encoding for α2δ subunits of voltage-gated calcium channels have
been linked to synaptic functions and neurological disease. Here we show that α2δ subunits …

The auxiliary subunit α2δ2 modulates the abundance and function of voltage-gated calcium
channels. Here we show that α2δ2 mRNA is expressed in neonatal and mature hair cells. A …

Abstract Cav1. 4 L-type Ca 2+ channels are predominantly expressed in retinal neurons,
particularly at the photoreceptor terminals where they mediate sustained Ca 2+ entry …