The pan-cancer landscape of prognostic germline variants in 10,582 patients

A Chatrath, R Przanowska, S Kiran, Z Su, S Saha… - Genome medicine, 2020 - Springer
Background While clinical factors such as age, grade, stage, and histological subtype
provide physicians with information about patient prognosis, genomic data can further …

Evolving castration resistance and prostate specific membrane antigen expression: implications for patient management

K Kessel, C Bernemann, M Bögemann, K Rahbar - Cancers, 2021 - mdpi.com
Simple Summary This review is a summary of recent findings on the role of prostate-specific
membrane antigen (PSMA) in metastatic castration-resistant prostate cancer (mCRPC) and …

Updates in prostate cancer research and screening in men at genetically higher risk

EK Bancroft, HN Raghallaigh, EC Page… - Current Genetic Medicine …, 2021 - Springer
Abstract Purpose of Review Prostate cancer (PrCa) is the most common cancer in men in
the western world and is a major source of morbidity and mortality. Currently, general …

PARP inhibitors in advanced prostate cancer in tumors with DNA damage signatures

CS McNevin, K Cadoo, AM Baird, SP Finn… - Cancers, 2022 - mdpi.com
Simple Summary This review paper seeks to summarize the current literature on the role of
PARP Inhibitors in Advanced Prostate Cancer in tumors with defects in genes associated …

Factors influencing survival in metastatic castration-resistant prostate cancer therapy

M Marchioni, L Marandino, D Amparore… - Expert Review of …, 2022 - Taylor & Francis
Introduction The number of patients with metastatic castration-resistant prostate cancer
(mCRPC) is expected to increase due to the long life expectancy of those with advanced …

The impact of genetic aberrations on response to radium‐223 treatment for castration‐resistant prostate cancer with bone metastases

AJ Liu, HE Kosiorek, BE Ueberroth, E Jaeger… - The …, 2022 - Wiley Online Library
Abstract Background Radium (Ra)‐223 is an established treatment option for patients with
metastatic castrate‐resistant prostate cancer (mCRPC) who have symptomatic bone …

Prostate cancer and liquid biopsies: Clinical applications and challenges

F Urabe, T Sumiyoshi, K Tashiro, T Goto… - … Journal of Urology, 2024 - Wiley Online Library
Liquid biopsy has emerged as a valuable and minimally invasive tool for real‐time detection
of clinically actionable abnormalities across various cancer types. Its applicability is …

Distinct response to platinum-based chemotherapy among patients with metastatic castration-resistant prostate cancer harboring alterations in genes involved in …

L Fan, X Fei, Y Zhu, C Chi, J Pan, J Sha, Z Xin… - The Journal of …, 2021 - auajournals.org
Purpose: We aimed to explore the association between genomic status and clinical outcome
of platinum-based chemotherapy among patients with metastatic castration-resistant …

DNA damage repair deficiency in prostate cancer

S Burdak-Rothkamm, WY Mansour, K Rothkamm - Trends in Cancer, 2020 - cell.com
Molecular-targeted therapies and treatment stratification based on molecular biomarkers
have rapidly gained momentum in the therapeutic spectrum for patients with prostate cancer …

Contribution of inherited DNA-repair gene mutations to hormone-sensitive and castrate-resistant metastatic prostate cancer and implications for clinical outcome

S Yadav, SN Hart, C Hu, D Hillman, KY Lee… - JCO Precision …, 2019 - ascopubs.org
PURPOSE To compare the prevalence of germline mutations in metastatic hormone-
sensitive prostate cancer (mHSPC) and metastatic castrate-resistant prostate cancer …