The pan-cancer landscape of prognostic germline variants in 10,582 patients
Background While clinical factors such as age, grade, stage, and histological subtype
provide physicians with information about patient prognosis, genomic data can further …
provide physicians with information about patient prognosis, genomic data can further …
Evolving castration resistance and prostate specific membrane antigen expression: implications for patient management
K Kessel, C Bernemann, M Bögemann, K Rahbar - Cancers, 2021 - mdpi.com
Simple Summary This review is a summary of recent findings on the role of prostate-specific
membrane antigen (PSMA) in metastatic castration-resistant prostate cancer (mCRPC) and …
membrane antigen (PSMA) in metastatic castration-resistant prostate cancer (mCRPC) and …
Updates in prostate cancer research and screening in men at genetically higher risk
EK Bancroft, HN Raghallaigh, EC Page… - Current Genetic Medicine …, 2021 - Springer
Abstract Purpose of Review Prostate cancer (PrCa) is the most common cancer in men in
the western world and is a major source of morbidity and mortality. Currently, general …
the western world and is a major source of morbidity and mortality. Currently, general …
PARP inhibitors in advanced prostate cancer in tumors with DNA damage signatures
Simple Summary This review paper seeks to summarize the current literature on the role of
PARP Inhibitors in Advanced Prostate Cancer in tumors with defects in genes associated …
PARP Inhibitors in Advanced Prostate Cancer in tumors with defects in genes associated …
Factors influencing survival in metastatic castration-resistant prostate cancer therapy
M Marchioni, L Marandino, D Amparore… - Expert Review of …, 2022 - Taylor & Francis
Introduction The number of patients with metastatic castration-resistant prostate cancer
(mCRPC) is expected to increase due to the long life expectancy of those with advanced …
(mCRPC) is expected to increase due to the long life expectancy of those with advanced …
The impact of genetic aberrations on response to radium‐223 treatment for castration‐resistant prostate cancer with bone metastases
AJ Liu, HE Kosiorek, BE Ueberroth, E Jaeger… - The …, 2022 - Wiley Online Library
Abstract Background Radium (Ra)‐223 is an established treatment option for patients with
metastatic castrate‐resistant prostate cancer (mCRPC) who have symptomatic bone …
metastatic castrate‐resistant prostate cancer (mCRPC) who have symptomatic bone …
Prostate cancer and liquid biopsies: Clinical applications and challenges
F Urabe, T Sumiyoshi, K Tashiro, T Goto… - … Journal of Urology, 2024 - Wiley Online Library
Liquid biopsy has emerged as a valuable and minimally invasive tool for real‐time detection
of clinically actionable abnormalities across various cancer types. Its applicability is …
of clinically actionable abnormalities across various cancer types. Its applicability is …
Distinct response to platinum-based chemotherapy among patients with metastatic castration-resistant prostate cancer harboring alterations in genes involved in …
L Fan, X Fei, Y Zhu, C Chi, J Pan, J Sha, Z Xin… - The Journal of …, 2021 - auajournals.org
Purpose: We aimed to explore the association between genomic status and clinical outcome
of platinum-based chemotherapy among patients with metastatic castration-resistant …
of platinum-based chemotherapy among patients with metastatic castration-resistant …
DNA damage repair deficiency in prostate cancer
Molecular-targeted therapies and treatment stratification based on molecular biomarkers
have rapidly gained momentum in the therapeutic spectrum for patients with prostate cancer …
have rapidly gained momentum in the therapeutic spectrum for patients with prostate cancer …
Contribution of inherited DNA-repair gene mutations to hormone-sensitive and castrate-resistant metastatic prostate cancer and implications for clinical outcome
PURPOSE To compare the prevalence of germline mutations in metastatic hormone-
sensitive prostate cancer (mHSPC) and metastatic castrate-resistant prostate cancer …
sensitive prostate cancer (mHSPC) and metastatic castrate-resistant prostate cancer …