VER A DECADE HAS passed since ''Immunologic Classification of Leukemia and
Lymphoma''by Foon and Todd was published in Blood. 1 Over this decade, flow Acute …

Because there are differing opinions regarding treatment of patients in the chronic phase of
chronic myeloid leukemia (CML), the American Society of Hematology convened an expert …

The" Harrison's" name is synonymous with internal medicine. From its unique section on
signs and symptoms through to the most comprehensive coverage of most all conditions …

Abstract Treatment for chronic myeloid leukemia (CML) has evolved from chemotherapy
(busulfan, hydroxyurea) to interferon-α (IFNα), and finally to tyrosine kinase inhibitors such …

Interferons (IFNs) are pleiotropic cytokines that exhibit multiple biological effects on cells and
tissues. IFN receptors are expressed widely in mammalian cells and virtually all different cell …

The chronological history of the important discoveries leading to our present understanding
of the essential clinical, biological, biochemical, and molecular features of chronic …

The mechanisms by which interferon-α (IFN-α) mediates its anti-leukemic effects in chronic
myelogenous leukemia (CML) cells are not known. We determined whether p38 MAPK is …

Interferon‐α (IFN‐α)(IFN‐α2b) is an immunoregulatory cytokine that is presently used in a
recombinant form for the treatment of tumours and chronic viral infection. However, its …

Biological agents have long been used in the treatment of cancer, and interferon-alpha was
the first human cytokine to be widely studied in this setting. Chronic myeloid leukemia (CML) …

In the last decade, improvements in both non-transplant and transplant therapy have
extended the lives of patients with CML, particularly those in chronic phase. The future will …