Bone marrow microenvironment plays a crucial role in the leukemogenic process. New
studies suggest that the bone marrow vascularity changes significantly in the leukemic …

OBJECTIVE: The mechanisms by which interferon α (IFN-α) induces antileukemic responses
in chronic myelogenous leukemia (CML) cells are not known. We examined whether a …

PURPOSE To evaluate the cost-effectiveness of interferon alfa (IFN alpha) treatment of
patients with chronic myelogenous leukemia relative to conventional chemotherapy …

The aims of this study were (1) to evaluate the effect of intermediate (cyclophosphamide
alone) or intensive (mitoxantrone, cytosine arabinoside, cyclophosphamide) priming on the …

Between January 1989 and July 1995 the search for an unrelated donor (UD) was started
for 379 consecutive Italian patients with Philadelphia positive (Ph+) chronic myelogenous …

Purpose: In this study, we have compared patterns of gene expression and functional activity
of human dendritic cells (DCs) cultured under defined conditions in IFN-α-2b and …

IL-15 and SCF fail to induce NK differentiation and proliferation of CD34+ hematopoietic
progenitors from chronic myeloid leukemia patients in contrast to normal stem cells …

Chronic myelogenous leukemia (CML) is a malignant disorder of the human hematopoietic
stem cell95 characterized by the Philadelphia chromosome (Ph). 195,222 The disease …

Background Analysis of published survival curves can be used as the basis for incremental
cost-effectiveness analyses in which two treatments are compared with one another in terms …

Results in 164 patients who underwent allogeneic marrow transplantation following
busulfan and cyclophosphamide over a 15 year period were analyzed. Age (median 37 …