Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated
mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury …

Impaired cardiac microvascular function contributes to diabetic cardiovascular complications
although effective therapy remains elusive. Empagliflozin, a sodium-glucose cotransporter 2 …

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) regulates cell death. We
sought to determine whether DNA-PKcs played a role in the tubular damage that occurs …

Abstract Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to
sustain mitochondrial homeostasis under stress conditions. However, no study has …

Obesity and its complications have become a prominent global public health problem that
severely threatens human health. Melatonin, originally known as an effective antioxidant, is …

Melatonin, along with its metabolites, have long been known to significantly reduce the
oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a …

Disturbed mitochondrial homeostasis contributes to the pathogenesis of cardiac ischemia
reperfusion (IR) injury, although the underlying mechanism remains elusive. Here, we …

Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the
world's population. NAFLD includes a spectrum of progressive liver disease from steatosis to …