Hydrogen peroxide is generated in numerous biological processes and is implicated as the
main transmitter of redox signals. Although a strong oxidant, high activation energy barriers …

Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control
cytokine-induced peroxide levels which mediate signal transduction in mammalian cells …

Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific
pore in the inner mitochondrial membrane, known as the mitochondrial permeability …

Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved
cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides …

I. Introduction II. Classification of Plant Prxs and Their Distribution in Plants and
Cyanobacteria III. Peroxidase Activity of Peroxiredoxins IV. Conformational Dynamics and …

Abstract Peroxiredoxin 6 (Prdx6) is the prototype and the only mammalian 1-Cys member of
the Prdx family. Major differences from 2-Cys Prdxs include the use of glutathione (GSH) …

Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic
principles, specificities and biological function. Peroxiredoxins are low efficiency …

Peroxiredoxin 6 represents a widely distributed group of peroxiredoxins that contain a single
conserved cysteine in the protein monomer (1-cys Prdx). The cys when oxidized to the …

Reactive oxygen species (ROS) are formed in mammalian cells as a consequence of
aerobic respiration. Despite multiple conserved redox modulating systems, a given …

Mycobacterium tuberculosis (Mtb) mounts a stubborn defense against oxidative and
nitrosative components of the immune response. Dihydrolipoamide dehydrogenase (Lpd) …