Arp2/3 complex nucleates branched actin filaments important for cellular motility and
endocytosis. WASP family proteins are Arp2/3 complex activators that play multiple roles in …

Natural killer (NK) cells eliminate abnormal cells through the release of cytolytic granule
contents. In this process, NK cells must adhere to target cells through integrin-mediated …

The formation of the branched actin networks is essential for cell polarity, but it remains
unclear how the debranching activity of actin filaments contributes to this process. Here, we …

Formation and turnover of branched actin networks underlies cell migration and other
essential force-driven processes. Type I nucleation-promoting factors (NPFs) such as WASP …

Wound healing requires a complex cascade of highly controlled and conserved cellular and
molecular processes. These involve numerous cell types and extracellular matrix molecules …

Arp2/3 complex nucleates branched actin filaments important for cellular motility,
endocytosis, meiosis, and cellular differentiation [1–4]. Wiskott-Aldrich syndrome proteins …

NPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane
glycoprotein mostly recognized for its key role in facilitating cholesterol efflux. Mutations in …

Invadopodia are actin-rich membrane protrusions that facilitate cancer cell dissemination by
focusing on proteolytic activity and clearing paths for migration through physical barriers …

Cell migration is important for development and its aberrant regulation contributes to many
diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation …

Developmental disabilities are defined as disorders that result in the limitation of function
due to impaired development of the nervous system; these disabilities can be present in the …